周一发表的一项研究结果称，牛皮癣病人患淋巴瘤的可能性比未患牛皮癣的人高出将近三倍。
费城宾夕法尼亚大学的研究者表示，产生更高风险的原因尚不清楚。
“必须要进行更多的研究，才能确定淋巴瘤的发病率增长是否与严重牛皮癣、牛皮癣治疗或者多重因素的交互作用有关，”发表于11月期《皮肤病学文献集》（Archives of Dermatology）中的报告总结说。
研究者表示，他们在英国保存有800多万病人医疗记录的数据库中进行了随机取样调查，之后得出了这一结论。这些医疗记录中包括有在1988年至1996年间接受治疗、超过65岁的患者。
“与未得牛皮癣的人相比，牛皮癣患者患淋巴瘤的风险要高出三倍，”研究者说。“而在超过65岁的牛皮癣患者中，每年的淋巴瘤发病率在每10万人中还会多出122例。”
Arch Dermatol. 2003 Nov；139（11）：1425-1429.
Lymphoma Rates Are Low but Increased in Patients With Psoriasis： Results From a Population-Based Cohort Study in the United Kingdom.
Gelfand JM， Berlin J， Van Voorhees A， Margolis DJ.
Department of Dermatology and the Center for Clinical Epidemiology and Biostatistics， University of Pennsylvania， Philadephia. Dr Margolis has consulted for Novartis， Biogen， GlaxoSmithKline， and Amgen； Dr Van Voorhees has consulted for or received grants from Amgen， Boehringer， and IDEC Pharmaceuticals.
OBJECTIVE： To determine if the rate of lymphoma in patients with a history of psoriasis is different from the rate of lymphoma in patients without psoriasis. DESIGN： Cohort study. SETTING： Outpatient practices of general practitioners in the United Kingdom who contribute to the General Practice Research Database.Patients The population studied was a sample of 10% of the patients 65 years or older registered with a general practitioner contributing to the General Practice Research Database between 1988 and 1996.Main Outcome Measure The rate of lymphoma in patients with psoriasis compared with the rate of lymphoma in patients without psoriasis. RESULTS： There were 2718 patients who had psoriasis and 105 203 patients （the reference population） who did not have psoriasis. The median follow-up time was 46 months. We noted 276 lymphomas. Patients with psoriasis had a 2.95 relative rate of developing lymphoma （95% confidence interval， 1.83-4.76） compared with those without psoriasis. This estimate did not change after controlling for age and sex using the Cox multivariable proportional hazards model. The rate of lymphoma changed little when the patients treated with methotrexate or those who developed mycosis fungoides were excluded. Compared with the reference population， we found an additional 122 lymphomas per 100 000 patients annually among patients with psoriasis who were 65 years or older. CONCLUSIONS： These results indicate that patients with psoriasis are at increased risk for developing lymphoma. Additional studies are necessary to determine if the increased rate of lymphoma is related to psoriasis severity， psoriasis treatment， or an interaction between these risk factors.
